Jonathan Hanna Jonathan Hanna

My Daily Supplement Protocol

Today I'll break down my daily supplement protocol. What I take, when i take it and why. This is something that comes up a lot so I wanted to offer my thinking on the topic.

First, supplementation should be regarded as an assisting resource to boost your health. Perfect supplementation will not fix a lack of sleep, poor hydration or an absence of exercise. As the name suggests it is meant to supplement a healthy lifestyle. The vast majority of your results are going to come from three areas.

1-Whole food nutrition.

2-Training.

3-Sleep. These are not listed in order, all three of them need to be in relatively good order for you to expect sustained progress in a healthy way.

Certain specific supplementation may interfere with medications and/or health issues you may have. It is important to consult your Doctor regarding your daily supplementation.

Coq10- studies

Benefits-

Heart Health & Cardiovascular Disease: Extensive clinical guidelines indicate that CoQ10 reduces hospitalizations, vascular mortality, and symptom severity in patients with moderate-to-severe heart failure. It may also assist in lowering both systolic and diastolic blood pressure.

Cellular Energy & Athletic Performance: By taking part in the electron transport chain, CoQ10 boosts ATP (energy) production within cells. Studies on athletes indicate it can reduce markers of exercise-induced muscle damage and improve anaerobic performance.

Antioxidant Protection: CoQ10 helps neutralize free radicals, protecting cell membranes and DNA from oxidative damage.

Migraine Prevention: Supplementation is recognized by the Mayo Clinic as a helpful tool for preventing migraines.

Metabolic & Fertility Support: Research shows it can decrease insulin resistance, lower inflammation, and regulate testosterone in conditions like Polycystic Ovary Syndrome (PCOS).

Dosage/Timing - 300-400mg/day. Take in the morning with a meal that has dietary fat. See notes below on importance of taking it in the morning.

Maximized Absorption: CoQ10 relies on dietary fats to be absorbed efficiently. Taking it with breakfast (e.g., eggs, avocado, or yogurt) increases absorption, whereas taking it on an empty stomach can lead to substantially less absorption.

Energizing Effects: CoQ10 boosts cellular energy production. Taking it early in the day aligns with your circadian rhythm and boosts daytime energy.

Sleep Quality: For some people, CoQ10 acts as a mild stimulant. Taking it in the evening or close to bedtime may cause difficulty falling asleep or insomnia

Creatine- studies

Creatine is one of the most rigorously studied and effective sports supplements available. Research shows that creatine monohydrate significantly improves muscle strength, increases lean body mass, and boosts power during short, high-intensity activities. Furthermore, it supports brain health by enhancing cognitive processing, attention, and memory. For a multitude of reasons you need to make sure you are properly hydrated. Taking creatine while chronically underhydrated may cause kidney and liver damage.

Physical Performance & Muscle Growth

Strength & Power: Supplementation increases phosphocreatine in muscles, enabling faster regeneration of adenosine triphosphate (ATP) during intense anaerobic bursts.

Hypertrophy: When combined with heavy resistance training, creatine leads to greater gains in lean body mass and muscle morphology.


Brain Function & Cognitive Health

Mental Fatigue: By increasing brain phosphocreatine levels, creatine supports brain bioenergetics. This helps sustain cognitive functioning and information processing speeds during periods of metabolic stress like sleep deprivation or mental fatigue.

Memory & Attention: Systematic reviews indicate measurable improvements in domains like memory and attention span, particularly in vegetarians and older adults who may have lower baseline levels.

Dosage/Timing- 5g/day. Take it when you are most likely to remember taking it. Consistency is more important than timing here. Effective dosage may differ for cognitive benefits compared to physical performance benefits. Higher dosages(10-20g) may be required.

Collagen-studies

Joint & Bone health

Osteoarthritis Support: Clinical studies suggest that collagen peptides may be effective in reducing joint stiffness and relieving pain in individuals suffering from knee osteoarthritis.

Athletic Recovery: Research on recreational athletes indicates that collagen supplementation can aid in improving joint functionality and reducing activity-related joint pain.

Dosage/Timing- 20g/day is tolerated well by most people. Timing is not super important here.

Krill Oil- studies

Heart Health & Cholesterol: Research summarized by the Cleveland Clinic Health Essentials indicates that krill oil can effectively reduce total cholesterol and triglycerides while potentially increasing "good" HDL cholesterol. A study in ScienceDirect.com confirmed it significantly lowers "bad" LDL cholesterol.

Joint & Arthritis Support: Clinical evidence suggests krill oil reduces pain, stiffness, and inflammation in patients with rheumatoid arthritis. One study found that taking 300 mg daily for 30 days significantly improved symptoms.

Skin Health: Recent findings from the National Institutes of Health (.gov) explore its potential for maintaining skin hydration, improving elasticity, and protecting against UV-induced damage.

Muscle Function: Studies on aging adults show that six months of supplementation can increase knee extensor strength and grip strength.

Brain Health: While more human data is needed, Healthline notes its high phospholipid content may make it more neuroprotective and easier for the brain to absorb than standard fish oil.

PMS Relief: Clinical trials have found that krill oil significantly reduces physical and emotional PMS symptoms, sometimes outperforming fish oil in managing irritability and stress.

Dosage/Timing- It is important to take your krill oil with dietary fat to ensure proper absorption. 500-1000mg is an appropriate dosage.

Triple Magnesium- studies

"Triple magnesium" supplements combine three highly absorbable forms of magnesium (typically glycinate, malate, and citrate or oxide). Research shows this combination optimizes absorption across different pathways, providing proven benefits like improved sleep quality, reduced anxiety, lowered blood pressure, and better muscle function without the digestive distress often caused by a single source.

1. Magnesium Glycinate (Brain & Sleep)

Benefits: Known for its calming effects on the nervous system, it is highly studied for reducing anxiety, combating insomnia, and preventing migraines.The Studies: Research indicates that magnesium bisglycinate increases sleep efficiency, decreases sleep onset latency, and helps lower cortisol (the stress hormone). Because the amino acid glycine crosses the blood-brain barrier, it is also highly recommended by experts for managing stress.

2. Magnesium Malate (Energy & Muscle Support)

Benefits: Formulated with malic acid, a compound found in fruits, this type supports energy production at a cellular level. It is the premier choice for combating muscle soreness, fatigue, and muscle spasms.The Studies: Studies have frequently explored magnesium malate for its efficacy in managing pain, improving cellular energy in muscles, and alleviating symptoms associated with fibromyalgia.

3. Magnesium Citrate or Oxide (Digestion & Absorption)

Benefits: Citrate is highly bioavailable and brings water into the intestines to safely alleviate constipation. Oxide serves as a dense, basic magnesium source used to quickly address systemic deficiencies and relieve heartburn.The Studies: Clinical trials continuously show magnesium citrate's high absorption rate, making it ideal for maintaining baseline nerve, bone, and heart health.

Dosage/Timing- 200-350mg/day is the typical dosage for triple magnesium supplements. To optimize your sleep this should be taken 30-60 minutes before bed.

Electrolytes- studies

Electrolytes provide essential minerals like sodium, potassium, and magnesium—are critical for regulating fluid balance, muscle contractions, and nerve signals. Studies show they are vital for rehydration after illness or intense sweating. However, for most everyday activities and light exercise, a balanced diet provides sufficient electrolytes, and extra supplements are often unnecessary.

Optimal Hydration: Electrolytes pull water into your cells. Studies, such as those on the Beverage Hydration Index, indicate that specific electrolyte-carbohydrate combinations enhance fluid retention compared to plain water.

Muscle and Nerve Function: Minerals like sodium and potassium generate electrical impulses needed for muscle contractions and steady heartbeats. While many commercial drinks claim to prevent cramps, research indicates this is not universally true, though proper balance is essential for preventing irregular heart rhythms.

Cognitive Performance: Research on hypo-hydration demonstrates that consuming electrolytes alongside water can prevent cognitive decline and quicker response times associated with mild dehydration.

Cardiovascular Health: Long-term epidemiological studies highlight the synergistic role of electrolytes in blood pressure regulation. For instance, a high potassium and low sodium diet is strongly associated with a decreased risk of stroke and unfavorable cardiovascular events.

Dosage/Timing- Dosage of electrolytes is dependent on activity level, temperature(environmental temperature and body temp) humidity and if you are a salty sweater or not(this can be tested). This guide can be helpful to determine appropriate dosage for different scenarios. Timing is dependent on your exercise output, temperature and humidity. For extended exercise sessions(60+ minutes) it may benefit you to sip on an electrolyte mix during or prior to exercise.

Vitamin D- studies

Extensive research shows vitamin D is crucial for absorbing calcium to build healthy bones. Major studies—including Harvard's VITAL trial—also highlight its benefits in reducing advanced cancer risk by about 20%, slowing cellular aging by protecting telomeres, and supporting immune system regulation.

Bone Health: Promotes calcium absorption, preventing bone-thinning (osteoporosis) and fractures in older adults.

Cancer Risk Reduction: High-dose supplementation over 5 years is linked to a lowered risk of advanced or fatal cancers.

Anti-Aging & Cellular Health: Landmark studies suggest vitamin D protects chromosomal caps (telomeres), potentially slowing pathways of biological aging.

Immunity: Modulates immune function and decreases inflammatory responses.

Autoimmune Protection: Higher levels are associated with a decreased risk of multiple sclerosis and type 1 diabetes.

Dosage/Timing- Take vitamin D supplements in the morning with a meal that contains healthy fats (like avocado, eggs, or nuts). This maximizes fat-soluble absorption and avoids potential nighttime melatonin interference. The standard recommended daily dose is \(600\) to \(2,000\) IU, depending on your age and health needs.

This is not a perfect or exhaustive list. Your needs can and likely will be different than mine. I exercise and sweat consistently so this protocol may not be best for you. As previously stated, consult your Doctor regarding your supplementation protocol. If you have any questions about specific products I’d be happy to answer. Shoot me an email using the contact page on the drop down menu.

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